Expresión de búsqueda: FLAP ENDONUCLEASES 
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Descriptor Inglés:   Flap Endonucleases 
Descriptor Español:   Endonucleasas de ADN Solapado 
Descriptor Portugués:   Endonucleases Flap 
Sinónimos Inglés:   FEN-1
Fen1 Protein
Flap Endonuclease-1
RAD2 Homolog-1 Nuclease
RTH-1 Nuclease
Endonuclease-1, Flap
Endonucleases, Flap
Flap Endonuclease 1
Nuclease, RTH-1
RAD2 Homolog 1 Nuclease
RTH 1 Nuclease  
Categoría:   D08.811.277.352.355.325.350
Definición Inglés:   Endonucleases that remove 5' DNA sequences from a DNA structure called a DNA flap. The DNA flap structure occurs in double-stranded DNA containing a single-stranded break where the 5' portion of the downstream strand is too long and overlaps the 3' end of the upstream strand. Flap endonucleases cleave the downstream strand of the overlap flap structure precisely after the first base-paired nucleotide, creating a ligatable nick. 
Nota Histórica Inglés:   2004; use FLAP ENDONUCLEASES (NM) 1994-2003; for FEN1 PROTEIN use EXODEOXYRIBONUCLEASE V 1997-2003; for RTH-1 NUCLEASE use EXODEOXYRIBONUCLEASE V 1996-2003 
Calificadores Permitidos Inglés:  
AD administration & dosage AE adverse effects
AN analysis AI antagonists & inhibitors
BI biosynthesis BL blood
CF cerebrospinal fluid CS chemical synthesis
CH chemistry CL classification
CT contraindications DF deficiency
DE drug effects EC economics
GE genetics HI history
IM immunology IP isolation & purification
ME metabolism PK pharmacokinetics
PD pharmacology PH physiology
PO poisoning RE radiation effects
SE secretion ST standards
SD supply & distribution TU therapeutic use
TO toxicity UL ultrastructure
UR urine  
Número del Registro:   38146 
Identificador Único:   D045585 

Ocurrencia en la BVS:
 

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